Abstract
We have recently demonstrated that the dietary supplement ProstaCaid™ (PC) inhibits growth and invasive behavior of PC-3 human prostate cancer cells in vitro. In the present study, we evaluated toxicity and whether PC suppresses growth of prostate cancer in a xenograft model of human prostate cancer cells implanted in mice. Here, we show that an oral administration of PC (100, 200 and 400 mg/kg) did not affect body weight or activity of liver enzymes (ALT, AST) and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. In addition, PC treatment resulted in the inhibition of tumor volumes (1024.6±378.6 vs. 749.3±234.3, P<0.001) in a xenograft model of prostate cancer with human hormone refractory (independent) PC-3 prostate cancer cells. Moreover, qRT-PCR analysis demonstrated significant upregulation of expression of CDKN1A (p21) and inhibition of expression of IGF2, NR2F2 and PLAU (uPA) genes by an oral administration of PC in prostate cancer xenografts. Our study demonstrates that the concentrations of the dietary supplement ProstaCaid tested did not show signs of toxicity, and its oral application has significant anticancer activity in vivo and can be considered as an alternative treatment for prostate cancer patients.
Authors
Jiahua Jiang, Jagadish Loganathan, Isaac Eliaz, Colin Terry, George E. Sandusky, Daniel Sliva – Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA, Amitabha Medical Clinic and Healing Center, Sebastopol, CA, USA, Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
PublicationPublished online on: Tuesday, January 24, 2012. Doi: 10.3892/ijo.2012.1344
The Safe Shopper's Bible
A Consumer's Guide to Nontoxic Household Products, Cosmetics and Food.
Take a look at the list below and write down how many products you have in your home right now!
Which products are safe and which may be harmful? Many items you buy every day contain ingredients that can cause allergic reaction, breathing difficulty, dizziness, cancer, birth defects, and other problems. Here, at last, is a comprehensive guide to answer all your questions about thousands of brand-name household products, personal care products, foods, and beverages.
According to this book, here is a list of common household products that contain known carcinogens and/or neurotoxins. Carcinogens are chemicals that cause cancer. Neurotoxins are chemicals that adversely affect the nervous system reducing emotional well being, mental alertness, coordination and other functions associated with intelligence.
Lysol disinfectant (all scents)
Renuzit Air Deodorizer
Bon Ami Foam Cleaner
Citri-Solv
Fantastik All-Purpose Cleaner
Formula 409
Pine-Sol Multi-Action Spray
Pledge Household Cleaner
Simple Green
Spic & Span Cleaner
Scotts Liquid Gold
Lemon Pledge
Tilex Soap Scum Remover
Glass Plus
Ajax Cleaner
Gillette Foamy Skin Conditioning
Speed Stick Deodorant
Soft Soap
Secret Deodorant
S.O.S. Ammonia Glass Cleaner
Dawn Sureshot
S.O.S. Vinegar Cleaner
Joy Dishwashing Liquid
Windex Glass Cleaner
Palmolive Dishwashing Liquid
Shout Aerosol & Stick
Sunlight Dishwashing Liquid
Spray & Wash Stain Remover
Kleen King Alum.& Copper Clnr
KR2 Spot Lifter
Behold Furniture Wax
Depend-o Blue Toilet Cleaner
Endust
3M Aerosol Spot Remover
Formby's Lemon & Almond Spray
Most Home & Garden Pesticides
Old English Furniture Spray
Dove Soap Bars
Right Guard Deodorant
Ponds Dry Skin Bar
Palmolive Skin Bar
Lady Speed Stick
Lever 2000
Irish Spring Deodorant
Lifebouy Soap
Jergens Liquid Soap
English Leather Deodorant
Ban Roll-on
Caress Body Bar
Camay
Ultra Brite Toothpaste
Cepacol Mouthwash
Crest Tartar Control
Listerine Original & Cool Mint
Arm & Hammer Toothpaste
Colgate toothpaste
Scope Mouthwash
The Safe Shopper's Bible
By David Steinman and Samuel S. Epstein M.D, 1995
A Consumer's Guide to Nontoxic Household Products, Cosmetics and Food
Switch stores now! Ask us how
June 02--NEW HAVEN -- A study conducted in part by researchers at the Yale School of Medicine suggests that a new drug that bolsters the immune system can shrink tumors in certain cancers -- including lung cancer, which has been resistant to treatment.
The tumors of about one-fourth of the study's 300 patients with non-small cell lung cancer, renal cell cancer and advanced melanoma significantly decreased in size after the patients were given the drug.
The study -- which was also authored by researchers from Johns Hopkins University, Harvard University, Bristol-Myers Squibb and other institutions -- appears Saturday in the New England Journal of Medicine. Several of the researchers are also presenting their findings at the annual meeting of the American Society of Clinical Oncology in Chicago this weekend.
The drug, known as BMS-936558, was developed by Bristol-Myers Squibb and is still in the study phase.
The drug is an antibody designed to restore the functions of lymphocyte cells, known as T-cells, and to foil tumors' ability to fight off the immune system.
"What happens is that the T-cells look for things that shouldn't be in the body," said co-author Scott Gettinger, associate professor of medicine at Yale.
But sometimes, Gettinger said, "there's a communication between the T-cell and the tumor, which tells the T-cell to not attack it." The drug, he said, "binds to the T-cell, which doesn't allow the negative communication."
Tumors shrank by at least 30 percent in 28 percent of the melanoma patients; a slightly smaller percentage of renal cancer patients had similar reductions in tumors. And 18 percent of the lung cancer patients had tumor reductions of 30 percent or more.
Gettinger said the progress made in the lung cancer tumors was most surprising.
"Immunotherapy has been tried for a long time in lung cancer in prior studies and it never amounted to much," he said.
Gettinger said the drug has to go through the U.S. Food and Drug Administration approval process so it could be years before it is widely available.
Right now 1 in 3 kids in America are over weight or obese, and the CDC predicts that 1 in 3 in our youngest generation will have diabetes in their lifetime.
This is a very sad statement because the outcome is totally avoidable. Join with our 800,000 plus fellow members that are doing something about their families health.
Contact us today and save your kids from becoming crippled by a preventable disease!
The American Journal of Clinical Nutrition published an article online on May 30, 2012 which revealed the finding of an international team of researchers of a reduction in mortality during 12.7 years of follow-up among men and women who consumed higher amounts of fiber. The study included 452,717 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study of different dietary patterns across ten European countries. The average age upon enrollment was 50.8 years. Questionnaires concerning diet, physical activity and other lifestyle factors completed upon recruitment were analyzed for total fiber intake (for which bread, vegetables and fruit were the most common sources). Over an average follow-up period of 12.7 years, 23,582 deaths occurred.
Subjects whose fiber intake was among the top 20 percent of participants at 28.5 grams or more per day had a 24 percent lower risk of dying from any cause over follow-up in comparison with those whose intake was among the lowest 20 percent at less than 16.4 grams daily. Each 10 gram per day increase in total fiber was associated with a 10 percent lower mortality risk. When deaths were examined by cause, a protective effect for fiber was observed for smoking-related cancers as well as circulatory, respiratory, digestive and inflammatory diseases. The greatest benefit was associated with digestive disorders, with men and women whose fiber intake levels were highest experiencing a 71 and 58 percent lower risk of dying from this cause than to those whose intake was lowest.
Fiber could promote health via several mechanisms, including helping to control weight, improving glycemic control, and aiding in the maintenance of a favorable intestinal environment. Fiber may help protect against circulatory diseases by lowering low density lipoprotein (LDL) cholesterol, which, when elevated, is a major risk factor for cardiovascular disease. Fiber intake has also been associated with a reduction in inflammatory markers including C-reactive protein, interleukin-6 and tumor necrosis factor-alpha. The authors note that greater total fiber intake could be a marker of an overall dietary pattern that benefits health.
"We observed inverse associations between total dietary fiber intake and mortality, and specifically mortality from circulatory, digestive, and non-cardiovascular disease, noncancer inflammatory diseases," the authors conclude. "These results show that high fiber intake, mainly from cereals and vegetables, may reduce the risk of death from these diseases."
May 30--Amid a table full of trays stacked with tortilla chips at Moe's Southwest Grill in Augusta, Shelby Kenrick proudly holds up a bag of apple slices. The 17-year-old from North Augusta is also the rare teen who thinks about fiber.
"That's what I eat for breakfast," she said, in the form of fiber bars.
Not many teens in Augusta are following her example, and it could have serious health consequences, said researchers at the Georgia Prevention Institute at Georgia Health Sciences University.
A study of more than 550 adolescents ages 14-18 recruited from Augusta high schools found that on average they got about 33 percent of the adequate amount of daily fiber, according to the report published online this month ahead of print in The Journal of Clinical Endocrinology & Metabolism.
Lower fiber intake was associated with an increase in visceral adipose tissue -- or belly fat -- and markers for increased inflammation, the study found. That kind of chronic inflammation is associated with the potential to develop health problems such as diabetes.
"Both high levels of inflammatory markers and high levels of visceral fat are associated with insulin insensitivity," said co-author Dr. Norman Pollock, an assistant professor of pediatrics in the institute at GHSU, a condition that can lead to diabetes
It is the first study to look at the impact of fiber intake in adolescents, he said. But the evidence of a growing problem in teens is already out there. A study published online last week in the journal Pediatrics found the rate of teens with diabetes or pre-diabetes increased from 9 percent in 1999 to 23 percent in 2008.
"That's a dramatic increase in prevalence in U.S. adolescents," Pollock said. And part of the problem could be diet.
"A lot of literature out there suggests that adolescents are not getting enough fruits and vegetables in their diet," he said. "That could be one big reason they are not getting the recommended amounts of fiber."
The next step could be looking at ways to get more fiber in teens' diets, which can be tricky, Pollock said.
"We can't get the kids to eat fruits and vegetables and that's another issue altogether," he said. One idea is to try adding a powder to their food or giving them fortified yogurt or smoothies, said Pollock, whose group is looking for a grant to try an interventional study. Whatever the solution is, it has to be their choice to do it, he said.
"They have to like it," Pollock said.
For Kelly Tinsley, 17, of North Augusta, fruits and vegetables are part of her home life.
"My parents are vegetarians, so I have to," she said.
Berlin (dpa) - Walking even short distances, linked to accompanying coordination and stretching exercises, has a measurable effect on general health, helping to reduce weight, improve the Body Mass Index and reduce blood pressure.
The conclusions result from a study conducted at the University of Halle Wittenberg in Germany and publicized by the German Hikers' Association.
The association has developed a health walking course together with physiotherapists. For seven weeks, 18 people working in various professions met twice a week to walk and exercise according to the programme. A group of 16 people, from the same age group, not exercising served as a control group.
"The walks were set for one-and-a-half hours," Christine Merkel of the association told dpa. Depending on the terrain, the walkers covered between 3.7 and 5.6 kilometres per session.
The participants, who were aged on average 53.6 years and who were not involved in any other sporting activity, spent one hour of each session exercising. They would stop twice during the walk to do exercises set by the physiotherapists.
"For example, there were exercises to loosen the shoulder muscles or to improve coordination - for example standing on one leg, with eyes open and then with eyes closed, or balancing a stick on the foot," Merkel said.
Other aspects covered were progressive muscle relaxation and three minutes of rapid walking, and an expert was on hand to provide tips on a healthy lifestyle.
The researchers recorded data on the health of the subjects and of the control group before the study commenced and again after seven weeks. No change was found in the control group, but for those participating in the health walking course their average weight loss was 1.3 kilograms.
Blood pressure values improved, heart rates at the same walking pace dropped from 131 to 122, and so-called endurance - measured on the basis of lactate values and blood oxygen content - increased. In addition, coordination skills also improved, as measured by standing on one leg on a moving board.
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